发明名称 |
Crystal of egfr extracellular domain and cetuximab fab fragment, and uses thereof |
摘要 |
The present invention relates to co-crystals of cetuximab Fab in a complex with extracellular domain of EGFR, and structure coordinates obtained from such crystal. Such coordinates are useful for identifying mimetics that bind to the extracellular domain of EGFR. Such mimetics may for example inhibit binding of ligand to EGFR, inhibit activation of EGFR, and/or reduce proliferation of tumor cells.
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申请公布号 |
US2011142822(A1) |
申请公布日期 |
2011.06.16 |
申请号 |
US20050629415 |
申请日期 |
2005.06.14 |
申请人 |
KUSSIE PAUL H;FERGUSON KATHRYN M |
发明人 |
KUSSIE PAUL H.;FERGUSON KATHRYN M. |
分类号 |
A61K39/395;A61P35/00;C07K16/00;C40B30/02;G01N33/53;G06F19/00 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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