发明名称 |
IMPROVED METHODS AND COMPOSITIONS FOR VEIN HARVEST AND AUTOGRAFTING |
摘要 |
The leading cause of graft failure is the subsequent development of intimal hyperplasia, which represents a response to injury that is thought to involve smooth muscle proliferation, migration, phenotypic modulation, and extracellular matrix (ECM) deposition. Surgical techniques typically employed for vein harvest - stretching the vein, placing the vein in low pH, solutions, and the use of toxic surgical skin markers - are shown here to cause injury. The invention therefore provides for non-toxic surgical markers than also protect against stretch-induced loss of functional viability, along with other additives. Devices and compositions for reducing physical stress or protecting from the effects flowing therefrom, also are provided. |
申请公布号 |
CA2783236(A1) |
申请公布日期 |
2011.06.16 |
申请号 |
CA20102783236 |
申请日期 |
2010.12.08 |
申请人 |
VANDERBILT UNIVERSITY;THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERAN S AFFAIRS |
发明人 |
BROPHY, COLLEEN;KOMALAVILAS, PADMINI;CHEUNG-FLYNN, JOYCE;HOCKING, KYLE;EAGLE, SUSAN |
分类号 |
A61K35/44;A61K31/185;A61M39/06 |
主分类号 |
A61K35/44 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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