INTERLEUKIN-1 RECEPTOR ANTAGONIST COMPOSITIONS AND METHODS OF MAKING AND USING SAME

摘要

The present invention relates to compositions comprising IL- 1ra linked to extended recombinant polypeptide (XTEN), isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of making and using such compositions in the treatment of IL- 1 -related diseases, disorders, and conditions.