发明名称 |
STABLE AQUEOUS COMPOSITIONS OF PROSTGLANDIN AGONIST PRODRUGS AND METHODS FOR USE THEREOF |
摘要 |
The present invention is based on the discovery that a marked increase in aqueous stability (and thereby shelf life) of prostanoid agonist prodrug compositions is achieved by incorporating into the compositions certain well-defined carboxylic acids, and thereafter adjusting the pH of the compositions from about 4.0 to about 8Ø As a result, the compositions and methods of the invention provide the aqueous stability required for marketable topical drug treatments of a wide variety of ocular disorders. |
申请公布号 |
CA2783707(A1) |
申请公布日期 |
2011.06.16 |
申请号 |
CA20102783707 |
申请日期 |
2010.11.05 |
申请人 |
ALLERGAN, INC. |
发明人 |
BURK, ROBERT M.;IM, WHA-BIN |
分类号 |
A61K9/08;A61K31/4025;A61K31/4436;A61K47/12;A61P27/06 |
主分类号 |
A61K9/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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