Methods of enhancing the efficacy of antibody-directed cellular cytotoxicity (ADCC) for therapy directed to killing of tumor cells are disclosed. Cancer specific cell surface antigens are bound by monoclonal antibodies, thereby stimulating a cytotoxic T cell response characterized by an upregulation of cell surface expression of costimulatory molecules on the T cell. The ADCC response is augmented by the subsequent administration of a second antibody that is an agonist of the costimulatory molecule.
申请公布号
CA2781311(A1)
申请公布日期
2011.06.16
申请号
CA20102781311
申请日期
2010.12.07
申请人
THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
发明人
KOHRT, HOLBROOK;HOUOT, ROCH;LEVY, RONALD;ALIZADEH, ARASH ASH;GOLDSTEIN, MATTHEW J.;TORCHIA, JAMES