摘要 |
A method for forming a cardiovascular structure in culture is provided. The method includes applying mechanical force to a cell population in culture such that a cardiovascular structure is formed. In some embodiments, the mechanical force is produced in culture medium by a pulsatile liquid flow with a retrograde component. The cell population can include stem cells or differentiated cells, or combinations of both. In particular embodiments, a cardiovascular valve is formed. Scaffolds for the support and growth of the cell population, and bioreactors including the scaffolds, are also provided. |
申请人 |
CALIFORNIA INSTITUTE OF TECHNOLOGY;GHARIB, MORTEZA;RINDERKNECHT, DEREK;FOROUHAR, ARIAN;VERMOT, JULIEN;FRASER, SCOTT, E. |
发明人 |
GHARIB, MORTEZA;RINDERKNECHT, DEREK;FOROUHAR, ARIAN;VERMOT, JULIEN;FRASER, SCOTT, E. |