发明名称 |
SELECTIVE BETA-GLUCURONIDASE INHIBITORS AS A TREATMENT FOR SIDE EFFECTS OF CAMPTOTHECIN ANTINEOPLASTIC AGENTS |
摘要 |
<p>Compounds, compositions and methods are provided that comprise selective ß-glucuronidase inhibitors for both aerobic and anaerobic bacteria, especially enteric bacteria normally associated with the gastrointestinal tract. The compounds, compositions and methods can be for inhibiting bacterial ß-glucuronidases and for improving efficacy of camptothecin-derived antineoplastic agents or glucuronidase-substrate agents or compounds by attenuating the side effects caused by reactivation by bacterial ß-glucuronidases of glucuronidated metabolites of camptothecin-derived antineoplastic agents or glucuronidase-substrate agents or compounds.</p> |
申请公布号 |
CA2783701(A1) |
申请公布日期 |
2011.06.16 |
申请号 |
CA20102783701 |
申请日期 |
2010.12.09 |
申请人 |
THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL;ALBERT EINSTEIN COLLEGE OF MEDECINE OF YESHIVA UNIVERSITY;NORTH CAROLINA CENTRAL UNIVERSITY |
发明人 |
REDINBO, MATTHEW R.;MANI, SRIDHAR;WILLIAMS, ALFRED;SCOTT, JOHN;YEH, LI-AN;WALLACE, BRET DAVID;LANE, KIMBERLY TERRY |
分类号 |
A61K31/4704;A61K31/381;A61K31/496;A61K31/519;A61K31/5377;A61P1/00;A61P1/12 |
主分类号 |
A61K31/4704 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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