PROCESS FOR ENANTIOMERICALLY PURE 8-ARYLOCTANOIC ACIDS AS ALISKIREN

摘要

The present invention relates to a novel manufacturing process and novel intermediates useful in the synthesis of pharmaceutically active compounds, especially rennin inhibitors such as Aliskiren. The invention describes a preparation of enantiomerically pure 8-aryloctanoic acids of general formula I from readily available key intermediate, chiral cis-diacid of formula II, aziridine of formula XI and a monocyclic compound of formula III. Formula (I) Formula (II) Formula (III) Formula (XI).