| 摘要 |
The present invention provides a slow release dosage form comprising a therapeutically effective amount of at least one form of axomadol, at least one pharmaceutically acceptable excipient wherein the said dosage form is suitable for once or twice daily administration. This invention also provides a method of treating a mammal by administering such slow release dosage forms. The present invention also provides a dosage form comprising a therapeutically effective amount of at least one form of axomadol, at least one pharmaceutically acceptable excipient, and at least one second active agent, wherein the second active agent is selected from a group consisting of acetaminophen, an NSADD, an Opioid, an Antiepileptic, a Norepinephrine Reuptake Inhibitor, a Serotonin Norepinephrine reuptake inhibitor (SNRI), a Cyclo-oxygenase-(COX)-inhibiting nitric oxide donator, NMDA (N-methyl-D-aspartic acid) Receptor antagonist, an Acetylcholinesterase inhibitor, a HT Agonist and a Proton Pump Inhibitor for treating a patient in need thereof and a method of treating a human comprising administration of such combination dosage forms of axomadol and at least one second active agent. |
