发明名称 |
METHOD FOR SELECTING A CANDIDATE DRUG COMPOUND |
摘要 |
<p>The invention relates to the field of candidate drug testing and drug development. The invention provides a method for selecting a candidate drug compound from among a library of compounds wherein binding of a target molecule is determined with said candidate compound bound to a solid support and also is determined with said candidate compound not bound to a solid support said method comprising selecting said candidate compound from among compounds composed of an invariant scaffold molecule to which a variant potential binding site molecule is linked. Furthermore, the invention relates to methods for attaching molecules to a scaffold. In particular, the invention relates to the synthesis of discontinuous or conformational binding sites or epitopes corresponding to or interacting with a binding molecule, in particular in relation to protein-protein or protein-ligand interactions.</p> |
申请公布号 |
EP1597585(B1) |
申请公布日期 |
2011.06.15 |
申请号 |
EP20040714981 |
申请日期 |
2004.02.26 |
申请人 |
PEPSCAN SYSTEMS B.V. |
发明人 |
TIMMERMAN, PETER;BELD, JORIS;MELOEN, ROBERT, HANS;PUIJK, WOUTER, CORNELIS |
分类号 |
G01N33/68;A61K31/00;A61K31/03;A61K38/00;C07K1/00;C07K1/02;C07K19/00;C40B30/04;G01N33/543 |
主分类号 |
G01N33/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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