发明名称 |
METHODS FOR THE CLASSIFICATION AND DIAGNOSIS OF SCOLIOSIS THROUGH THE USE OF GI PROTEIN COUPLED RECEPTOR |
摘要 |
Methods for diagnosing a predisposition to developing a scoliosis (e.g., adolescent idiopathic scoliosis (AIS)) and identifying compounds for treating scoliosis based on the modulation of Gi protein-coupled receptor activity are described. Specific embodiments of the methods involve measuring a change in impedance signals of cells expressing a receptor coupled to a Gi protein with a ligand. To identify compounds useful in treatment, the cell is contacted with a test compound and a ligand. A higher impedance in the presence relative to the absence of said test compound is indicative that the test compound is useful for treating scoliosis. |
申请公布号 |
EP2331962(A1) |
申请公布日期 |
2011.06.15 |
申请号 |
EP20090818732 |
申请日期 |
2009.10.13 |
申请人 |
CHU SAINTE-JUSTINE |
发明人 |
MOREAU, ALAIN;AKOUME NDONG, MARIE-YVONNE |
分类号 |
G01N33/566;G01N27/02;G01N33/50;G01N33/68 |
主分类号 |
G01N33/566 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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