发明名称 |
Uniform films for rapid dissolve dosage form incorporating taste-masking compositions |
摘要 |
A thin film drug delivery composition includes (i) a flowable water-soluble film forming matrix; (ii) a particulate bioeffecting agent uniformly stationed therein; and (iii) a taste-masking agent coated or intimately associated with the particulate to provide taste-masking of the bioeffecting agent. The combined particulate and taste-masking agent have a particle size of 200 microns or less and the flowable water-soluble film forming matrix is capable of being dried without loss of uniformity in the stationing of the particulate bioeffecting agent therein. The combined particulate and taste-masking agent have a particle size of 150 microns or less, for example 100 microns or less. Moreover, the flowable water-soluble film forming matrix is formable into a dry film of less than about 380 microns in thickness, for example less than about 250 microns in thickness. |
申请公布号 |
EP2332523(A1) |
申请公布日期 |
2011.06.15 |
申请号 |
EP20110157819 |
申请日期 |
2002.10.11 |
申请人 |
MONOSOL RX LLC |
发明人 |
FUISZ, RICHARD C.;YANG, ROBERT K.;MYERS, GARY L. |
分类号 |
A61K31/4545;A61K9/00;A61K9/16;A61K9/70;A61K45/00;A61K47/32;A61K47/34;A61K47/36;A61K47/38;A61K47/42;A61K47/44;A61P1/04;A61P11/10;A61P11/14;A61P25/04;A61P25/16;A61P29/00;A61P31/04;A61P37/08 |
主分类号 |
A61K31/4545 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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