| 发明名称 |
N-substituted azoles and their use as MEK-1 and/or ERK-2 modulators |
| 摘要 |
<p>The present invention provides realtes to N-substituted pyrroles, pyrazoles, imidazoles, triazoles and tetrazoles, and methods of treatment and pharmaceutical compositions that utilize or comprise one or more such compounds. Compounds of the invention are useful for a variety of therapies, including treating or preventing various cancers, inflammation, septic shock, preterm labor, infertility, pain, and ischemia, and other diseases and disorders associated with MEK-1 and/or ERK-2 activation.</p> |
| 申请公布号 |
EP2332922(A1) |
申请公布日期 |
2011.06.15 |
| 申请号 |
EP20100075495 |
申请日期 |
2002.10.23 |
| 申请人 |
MERCK SERONO S.A. |
发明人 |
ARKINSTALL, STEPHEN J;ARULANANDAM, ANTONIO;JIANG, XULIANG;MAGAR, SHARAD;NABIOULLIN, ROUSTEM;ZHANG, JOHN YINGSHENG;BLUME-JENSEN, PETER |
| 分类号 |
C07D233/60;A61K31/41;A61K31/4164;A61K31/417;A61K31/4178;A61K31/4196;A61K31/4439;A61P1/04;A61P1/14;A61P1/18;A61P3/10;A61P5/14;A61P7/00;A61P7/02;A61P7/06;A61P7/10;A61P9/00;A61P9/14;A61P11/00;A61P11/06;A61P13/12;A61P15/06;A61P15/08;A61P15/10;A61P17/00;A61P17/02;A61P19/00;A61P19/02;A61P19/10;A61P25/04;A61P25/28;A61P27/02;A61P29/00;A61P31/00;A61P31/04;A61P31/18;A61P35/00;A61P35/02;A61P35/04;A61P37/00;A61P37/02;A61P37/08;A61P43/00;C07D233/54;C07D233/61;C07D233/68;C07D249/08;C07D257/04;C07D401/12;C07D405/12 |
主分类号 |
C07D233/60 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
|
| 地址 |
|
