FUSED PROTEINS BINDING IMMUNOGLOBULIN DOMAIN

摘要

FIELD: medicine. ^ SUBSTANCE: offered is a fused protein containing from an amino-terminus to carboxyl terminus: binding domain polypeptide which is bound with a biological target molecule; human one-cysteine "link" region IgGl peptide; immunoglobulin heavy chain CH2 constant region polypeptide and immunoglobulin heavy chain CH3 constant region polypeptide. The fused protein represents mixed monomers and dimers, has ADCC, CDC or both cytotoxicities. Also, described are a pharmaceutical composition and a method of treating a B-cell disorder with using the fused protein. ^ EFFECT: use of the invention can find the further application in medicine in treating B-cell disorders. ^ 26 cl, 26 dwg, 9 ex