| 摘要 |
FIELD: medicine. ^ SUBSTANCE: invention refers to a compound of formula to its salt or hydrate where R1 represents hydrogen atom, alkyl group containing 1-6 carbon atoms or cycloalkyl group containing 3-6 carbon atoms; and alkyl group is optionally substituted by halogen atom; R2 represents hydrogen atom or alkyl group containing 1-6 carbon atoms; R3 represents alkyl group containing 1-6 carbon atoms or cycloalkyl group containing 3-6 carbon atoms; and alkyl group is optionally substituted by halogen atom; R4 and R5 independently represent hydrogen atom, halogen atom, alkyl group containing 1-6 carbon atoms, alkoxygroup containing 1-6 carbon atoms or alkenyl group containing 2-6 carbon atoms; and alkyl group is optionally substituted by halogen atom; and provided R4 and R5 are not hydrogen atoms simultaneously; or substitutes R4 and R5 together represent (a) 3-6-members cyclic compound including carbon atom, common for R4 and R5, with formation of a spirocyclic compound with a pyrrolidine ring; or (b) exomethylene group bound with the pyrrolidine ring by a double bond; R6 and R7 independently represent hydrogen atom or alkyl group containing 1-6 carbon atoms; R8 represents halogen-substituted alkyl group containing 1-6 carbon atoms or cycloalkyl group containing 3-6 carbon atoms; and cycloalkyl group can be substituted by halogen atom; R9 represents hydrogen atom; X1 represents hydrogen atom or halogen atom; and A represents nitrogen atom or a fragment presented by formula , where X2 represents hydrogen atom, alkyl group containing 1-6 carbon atoms or alkoxygroup containing 1-6 carbon atoms; or X2 together with R8 represents a cyclic compound containing a portion of a nucleus, and the ring formed thereby optionally contains oxygen atom and is substituted by alkyl group containing 1-6 carbon atoms. Besides, the invention refers to an antibacterial agent based on the compound of formula I, to a therapeutic agent for infections, to a method of treating an infectious disease and an application of said compounds for preparing an antibacterial drug. ^ EFFECT: there are produced and described new compounds showing strong antibacterial activity in relation to gram-positive and gram-negative bacteria. ^ 30 cl, 112 ex, 10 tbl, 4 dwg |
