发明名称 |
Stereoselective process for the production of dioxolane nucleoside analogues |
摘要 |
The present invention relates to a process for producing compounds of formula (I) and (VII); said process comprising the steps of: a) subjecting a compound of formula (II) to an enzymatic diastereomeric resolution in the presence of a suitable amount of enzyme chosen from Pig Liver Esterase or Porcine Pancreatic Lipase b) recovering said compounds of formula (I) and (VII). The invention also provides a process for producing compounds of formula (III) and (X); said process comprising the steps of: a) subjecting a compound of formula (IV) to an enzymatic diastereomeric resolution in the presence of a suitable amount of enzyme chosen from Candida Antarctica “A” lipase, Candida Antarctica “B” lipase, Candida Lypolitica Lipase or Rhizomucor Miehei Lipase b) recovering said compound of formula (III) and (X).
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申请公布号 |
US7955835(B2) |
申请公布日期 |
2011.06.07 |
申请号 |
US20050535235 |
申请日期 |
2005.12.19 |
申请人 |
SHIRE CANADA INC. |
发明人 |
CIMPOIA ALEX;LALONDE JAMES JOSEPH |
分类号 |
C12P41/00;C07D317/32;C12P17/04 |
主分类号 |
C12P41/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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