发明名称 |
FLUORO-CARBON EMULSION ENHANCEMENT AGENT FOR HIGH INTENSITY FOCUSED ULTRASOUND TREATMENT AND USE THEREOF |
摘要 |
The present invention discloses a fluoro-carbon emulsion enhancement agent for HIFU treatment, which can increase acoustic energy deposition at the target location during HIFU treatment. The enhancement agent comprises a discontinuous phase comprising of a core material encapsulated by a membrane-forming material and a continuous phase comprised of aqueous medium; the discontinuous phase is uniformly dispersed in the continuous phase and the particle size of the discontinuous phase ranges from 0.1-2µm; the amount of the membrane-forming material in the enhancement agent is 0.1-100g/L; the core material is comprised of a liquid that undergoes a liquid-gas phase transition at 38-100°C, and the amount of the core material in the enhancement agent is 5-200ml/L. The fluoro-carbon emulsion enhancement agent for HIFU treatment of the present invention can significantly change the acoustic environment of the target location and can increase acoustic energy deposition at the target location during HIFU treatment. Eventually, the ability of clinical HIFU treatment to ablate tumor cells can be significantly improved. Accordingly, the present invention discloses use of a fluoro-carbon emulsion enhancement agent for HIFU treatment during HIFU treatment.
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申请公布号 |
CA2593644(C) |
申请公布日期 |
2011.06.07 |
申请号 |
CA20052593644 |
申请日期 |
2005.09.02 |
申请人 |
CHONGQING HAIFU(HIFU) TECHNOLOGY CO., LTD |
发明人 |
WANG, ZHIBIAO;LI, FAQI;XIAO, ZIWEN;XIAO, YANBING;LIU, LIPING;WANG, ZHILONG |
分类号 |
A61K41/00;A61K9/127;A61K47/12;A61K47/14;A61K47/24;A61K47/44;A61N7/00 |
主分类号 |
A61K41/00 |
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