发明名称 |
FC FUSION PROTEINS FOR ENHANCING THE IMMUNOGENICITY OF PROTEIN AND PEPTIDE ANTIGENS |
摘要 |
<p>Disclosed herein are methods and compositions for enhancing the immunogenicity of a preselected protein or peptide antigen in a mammal. Immunogenicity is enhanced by fusing the preselected antigen to an immunoglobulin heavy chain constant region to produce an Fc-antigen fusion protein. The Fc-antigen fusion proteins bind Fc receptors on the surface of antigen presenting cells, thereby targeting the antigen to the antigen presenting cells in the mammal. In addition, disclosed is a family of adjuvants, for example, an Fc-adjuvant fusion protein, for use in combination with the Fc-antigen fusion proteins to enhance or modulate a particular immune response against the preselected antigen.</p> |
申请公布号 |
CA2378866(C) |
申请公布日期 |
2011.06.07 |
申请号 |
CA20002378866 |
申请日期 |
2000.07.21 |
申请人 |
LEXIGEN PHARMACEUTICALS CORP. |
发明人 |
GILLIES, STEPHEN D.;LO, KIN MING;WESOLOWSKI, JOHN S., JR. |
分类号 |
A61K39/39;A61K38/16;A61K39/00;A61K39/12;A61K39/21;A61K39/385;A61P37/04;C07K14/16;C07K14/475;C07K14/52;C07K14/535;C07K14/705;C07K19/00;C12N15/62;G01N33/53 |
主分类号 |
A61K39/39 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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