摘要 |
The present invention relates to novel methods of synthesis of therapeutic and diagnostic dendrimers. In particular, the present invention is directed to novel dendrimer conjugates, novel methods of synthesizing the same, compositions comprising the conjugates, as well as systems and methods utilizing the conjugates (e.g., in diagnostic and/or therapeutic settings (e.g., for the delivery of therapeutics, imaging, and/or targeting agents (e.g., in disease (e.g., cancer, inflammatory disease) diagnosis and/or therapy, pain therapy, etc.)). Accordingly, dendrimer conjugates of the present invention may further comprise at least two different components for targeting, imaging, sensing, and/or providing a therapeutic or diagnostic material and/or monitoring response to therapy. Furthermore, the novel synthesis methods of certain embodiments of the present invention provide significant advantages with regard to total reaction time and simplicity. |
申请人 |
THE REGENTS OF THE UNIVERSITY OF MICHIGAN;BAKER, JR., JAMES R.;ZHANG, YUEHUA;THOMAS, THOMMEY P.;DESAI, ANKUR MAHESH |
发明人 |
BAKER, JR., JAMES R.;ZHANG, YUEHUA;THOMAS, THOMMEY P.;DESAI, ANKUR MAHESH |