摘要 |
The hemitartrate salt of a compound represented by the following structural formula: (Formula I Hemitartrate), which may be used in pharmaceutical applications, are disclosed. Particular single crystalline forms of the Formula (I) Hemitartrate are characterized by a variety of properties and physical measurements. As well, methods of producing crystalline Formula (I) Hemitartrate, and using it to inhibit glucosylceramide synthase or lowering glycosphingolipid concentrations in subjects to treat a number of diseases, are also discussed. Pharmaceutical compositions are also described. |
申请人 |
GENZYME CORPORATION |
发明人 |
LIU, HARLAN;WILLIS, CHRISTOPHER;BHARDWAJ, RENU;COPELAND, DIANE P.;HARIANAWALA, ABIZER;SKELL, JEFFREY;MARSHALL, JOHN;KOCHLING, JIANMEI;PALACE, GERARD;PETERSCHMITT, JUDITH;SIEGEL, CRAIG;CHENG, SENG |