CELL-BASED ANTI-CANCER COMPOSITIONS AND METHODS OF MAKING AND USING THE SAME
摘要
Isolated pluralities of T cells which recognize at least one epitope of a mucosally restricted antigen and pharmaceutical compositions comprising the same are disclosed. Methods of making a plurality of T cells that recognize at least one epitope of a mucosally restricted antigen are also disclosed. Methods of treating an individual who has been diagnosed with cancer of a mucosal tissue or preventing such cancer in an individual at elevated risk are disclosed as are nucleic acid molecules that comprise a nucleotide sequence that encode proteins that recognize at least one epitope of a mucosally restricted antigen and T cells comprising such nucleic acid molecules.
申请公布号
WO2011066048(A1)
申请公布日期
2011.06.03
申请号
WO2010US53733
申请日期
2010.10.22
申请人
THOMAS JEFFERSON UNIVERSITY;WALDMAN, SCOTT, A.;SNOOK, ADAM, E.