摘要 |
A method of treating cancer or inhibiting metastasis in a subject by reducing intratumoral extracellular pH. The method includes the step of administering to the subject a therapeutically effective amount of a buffer having a pKa greater than 6.1. In an advantageous embodiment the pKa of the buffer is about 7.0. Examples of buffers for reducing extracellular pH include NaHCO3, the buffer is selected from the group consisting of 2-imidazole-1-yl-3-ethoxycarbonylpropionic acid (IEPA), cholamine chloride, N,N-Bis(2-hydroxyethyl)-2-aminoethanesulfonic acid (BES), N-Tris(hydroxymethyl)methyl-2-aminoethanesulfonic acid (TES) and 4-(2-Hydroxyethyl)piperazine-1-ethanesulfonic acid (HEPES). The method can further include the step of pretreating with one or more chemotherapeutic agents. |
申请人 |
H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.;GILLIES, ROBERT J.;MORSE, DAVID L.;SILVA, ARIOSTO S.;IBRAHIM HASHIM, ARIG A.;GATENBY, ROBERT A.;MARTINEZ, GARY |
发明人 |
GILLIES, ROBERT J.;MORSE, DAVID L.;SILVA, ARIOSTO S.;IBRAHIM HASHIM, ARIG A.;GATENBY, ROBERT A.;MARTINEZ, GARY |