PEPTIDE-BASED TREATMENT FOR NEURODEGENERATIVE DISEASES

摘要

Disclosed herein are peptide conjugates and methods for use of such for treating subjects with an axonal disorder. In an example, a conjugate includes a tetanus toxin peptide (Tet-1) with the amino acid sequence set forth by SEQ ID NO: 1 (HLNILSTLWKYR), an optional spacer moiety, an optional one or more amino acids, a tetrapeptide including at least two cysteine or two lysine residues. Methods of reducing or inhibiting one or more symptoms associated with an axonal disorder by administering a therapeutically effective amount of a pharmaceutical composition including a disclosed conjugate are also provided.