发明名称 |
Compositions And Methods For Inhibiting Expression Of Factor V Leiden Mutant Gene |
摘要 |
The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of the Factor V Leiden mutant gene (Factor V Leiden mutant gene), comprising an antisense strand having a nucleotide sequence which is less that 25 nucleotides in length and which is substantially complementary to at least a part of the Factor V Leiden mutant gene. The invention also relates to a pharmaceutical composition comprising the dsRNA together with a pharmaceutically acceptable carrier; methods for treating diseases caused by the expression of the Factor V Leiden mutant gene using the pharmaceutical composition; and methods for inhibiting the expression of the Factor V Leiden mutant gene in a cell.
|
申请公布号 |
US2011130443(A1) |
申请公布日期 |
2011.06.02 |
申请号 |
US201113010300 |
申请日期 |
2011.01.20 |
申请人 |
VORNLOCHER HANS-PETER;MARAGANORE JOHN M |
发明人 |
VORNLOCHER HANS-PETER;MARAGANORE JOHN M. |
分类号 |
A61K31/713;A61P7/02;C07H21/04;C12N5/10;C12N15/113;C12N15/63 |
主分类号 |
A61K31/713 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|