发明名称 METHOD FOR TREATING NEURODEGENERATIVE DISEASE
摘要 PROBLEM TO BE SOLVED: To provide a composition and a method for inhibitingα-synuclein (SNCA) gene expression such as for treatment of a neurodegenerative disorder. SOLUTION: An anti-SNCA agent featured herein to target the SNCA gene is modified to be distributed to neural cells preferentially. In one aspect, the method is to treat a target by administering a medicine which inhibits SNCA expression. In a preferable embodiment, the target is a mammal such as human beings or the like, for example, the target is one diagnosed to have the neurodegenerative disorder or to have a risk to have an onset of the neurodegenerative disorder. COPYRIGHT: (C)2011,JPO&INPIT
申请公布号 JP2011105761(A) 申请公布日期 2011.06.02
申请号 JP20110030292 申请日期 2011.02.15
申请人 ALNYLAM PHARMACEUTICALS INC;MAYO FOUNDATION FOR MEDICAL EDUCATION & RESEARCH 发明人 BUMCROT DAVID;FARRER MATTHEW J;MARAGANORE DEMETRIUS;VORNLOCHER HANS-PETER
分类号 A61K48/00;A61K;A61K31/713;A61P25/16;A61P25/28;C07H21/02;C12N15/113;C12Q1/02;C12Q1/68;G01N33/15;G01N33/50;G01N33/53 主分类号 A61K48/00
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