发明名称 |
METHOD AND KIT FOR DETECTION OF CANCER, AND THERAPEUTIC AGENT FOR CANCER |
摘要 |
The object aims to comprehensively analyze miRNA that undergoes epigenetic silencing in cancer to identify miRNA associated with cancer, elucidate the role of the identified miRNA in cancer, and develop a novel method for detecting cancer and a novel therapeutic agent for cancer both of which relate to the miRNA. Disclosed is a method for detecting cancer in a subject, which comprises detecting methylated CpG in a CpG island located in a promoter region of a microRNA 34b gene and/or a microRNA 34c gene in a biological sample collected from the subject. Also disclosed is a therapeutic agent for cancer, which comprises a nucleic acid encoding a BTG4 gene or BTG4, or comprises a nucleic acid encoding a miR-34b gene and/or an miR-34c gene or miR-34b and/or miR-34c.
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申请公布号 |
US2011130341(A1) |
申请公布日期 |
2011.06.02 |
申请号 |
US20090991335 |
申请日期 |
2009.05.07 |
申请人 |
SAPPORO MEDICAL UNIVERSITY |
发明人 |
SUZUKI HIROMU;TOYOTA MINORU;IMAI KOHZOH;SHINOMURA YASUHISA;TOKINO TAKASHI |
分类号 |
A61K38/17;A61K31/7088;A61P35/00;C07H21/00;C07H21/02;C07K14/47;C12Q1/68 |
主分类号 |
A61K38/17 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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