发明名称 |
Mat II Beta Subunit RNAi and Therapeutic Methods Using Same |
摘要 |
The presently disclosed subject matter generally relates to methods and compositions for modulating MAT II activity. More particularly, the presently disclosed subject matter relates to methods and compositions for inhibiting the expression of MAT II &bgr; subunit in a subject via RNAi by administering siRNA or shRNA molecules directed to MAT II &bgr; subunit. In some embodiments, the methods and compositions of the presently disclosed subject matter generally relates to the treatment of cancer. More particularly, the methods and compositions of the presently disclosed subject matter relates to the inhibition of MAT II &bgr; subunit for the treatment of leukemia.
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申请公布号 |
US2011129461(A1) |
申请公布日期 |
2011.06.02 |
申请号 |
US20090936780 |
申请日期 |
2009.04.07 |
申请人 |
UNIVERSITY OF CINCINNATI |
发明人 |
KOTB MALAK;GELLER ARTHUR M. |
分类号 |
A61K39/395;A61K31/7105;A61K38/00;A61P35/00;A61P35/02;C07H21/02;C12N5/071;C12N5/10;C12N15/11;C12N15/113;C12N15/115;C12N15/63;C12P19/34 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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