USE OF ANTAGONIST ANTI-CD40 ANTIBODY FOR TREATMENT OF AUTOIMMUNE AND INFLAMMATORY DISEASES AND ORGAN TRANSPLANT REJECTION

摘要

PROBLEM TO BE SOLVED: To provide a method for intervening into a CD40L-mediated CD40 signaling pathway bearing the important roll in the maintenance of normal immunization when accommodative insufficiency is caused.

SOLUTION: Methods of therapy for treating a subject for an autoimmune disease and/or inflammatory disease are provided. The methods comprise a step for administering a therapeutically effective amount of an antagonist anti-CD40 antibody or antigen-binding fragment thereof to a patient in need thereof. The antagonist anti-CD40 antibody or antigen-binding fragment thereof is free of significant agonist activity, but exhibits antagonist activity when the antibody binds a CD40 antigen on a human CD40-expressing cell. Antagonist activity of the anti-CD40 antibody or antigen-binding fragment thereof beneficially inhibits CD40L-mediated stimulation of CD40-expressing cells, and thus inhibits survival of the human CD40-expressing cells and signaling pathways of the human CD40-expressing cells that are mediated by CD40L.

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