发明名称 |
NON-CYTOTOXIC FUSION PROTEINS COMPRISING EGF MUTEINS |
摘要 |
The present invention relates to fusion proteins comprising a non-cytotoxic protease and a EGF mutein ligand. The EGF mutein provides improved EGF receptor activation for the claimed fusion proteins. Also provided is the use of said polypeptides as therapeutics for suppressing mucus hypersecretion, inflammation, endocrine neoplasia and/or neuroendocrine disorders, neuroendocrine tumors, for suppressing cancers such as colorectal cancer, prostate cancer, breast cancer, and lung cancer. |
申请公布号 |
EP2326665(A1) |
申请公布日期 |
2011.06.01 |
申请号 |
EP20090785502 |
申请日期 |
2009.08.19 |
申请人 |
SYNTAXIN LIMITED |
发明人 |
COSSINS, AIMEE;BIRCH-MACHIN, IAN;STANCOMBE, PATRICK;CHADDOCK, JOHN;BEARD, MATTHEW |
分类号 |
C07K14/485;A61K38/16;C07K14/33;C12N15/12;C12N15/62 |
主分类号 |
C07K14/485 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|