发明名称 |
COMPOSITION CONTAINING 4-O-METHYLHONOKIOL FOR TREATING OR PREVENTING AMYLOID- RELATED DISEASES |
摘要 |
Disclosed is a composition for treating or preventing amyloid-related diseases including 4-O-methylhonokiol as an active ingredient. More specifically, a pharmaceutical composition including 4-O-methylhonokiol, which is effective for treating or preventing amyloid-related diseases such as Alzheimer's disease, cognitive disorder, defective memory, amyloidosis, etc. is disclosed. The inventors of the present disclosure have found out for the first time that 4-O-methylhonokiol inhibits the production of ²-amyloid. It has been confirmed to be useful in treating or preventing amyloid-related diseases. Through animal tests including water maze test and passive avoidance test on mice, 4-O-methylhonokiol has been confirmed to be effective for amyloid-related diseases such as Alzheimer's disease, defective memory, cognitive disorder, and the like. It was further confirmed through acetylcholinesterase activity inhibition test using mouse brain cortex and hippocampus tissue that they are particularly effective in treating or preventing Alzheimer's disease among the amyloid-related diseases. |
申请公布号 |
EP2327402(A2) |
申请公布日期 |
2011.06.01 |
申请号 |
EP20090816445 |
申请日期 |
2009.09.25 |
申请人 |
BIOLAND LTD. |
发明人 |
KIM, KI HO;KIM, KI SOO;KIM, YOUNG HEUI;KIM, JIN GUK;KIM, KYOUNG TAE;HAN, CHANG SUNG;LEE, SANG IL |
分类号 |
A61K31/085;A23L1/30;A23L2/52;A61K36/575;A61P25/28 |
主分类号 |
A61K31/085 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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