ANTI-TUMOR DRUG DELIVERY SYSTEMS OF TERNARY BIOMOLECULAR NANOPARTICLES OF FOLATE RECEPTOR CONJUGATED HEPARIN

摘要

PURPOSE: A drug delivery system for anticancer and antitumor with ternary biomolecules conjugated with heparin is provided to support and release anticancer or antitumor drugs without side effects. CONSTITUTION: A drug delivery system for anticancer and antitumor contains ternary biomolecules containing heparin, aminized folic acid, and compounds with anticancer or antitumor activities. The heparin is a structure having hydroxy group(-OH), carboxy group(-COOH), and amino group(-NH_2). The compound with anticancer or antitumor activities contains carboxy group(-COOH) or amino group(-NH_2). The compouns is retinoic acid, paclitaxel, doxetaxel, vincristine, or vinorelbine.