发明名称 |
SYNTHETIC PEPTIDES CORRESPONDING TO OVERLAPPING NEUTRALIZING DETERMINANTS IN THE CBD1 EPITOPE INDUCE BROADLY NEUTRALIZING ANTIBODIES. |
摘要 |
The present invention relates to chimeric peptides having a caveolin-1 binding domain of an HIV-1 gp41 (CBD1) peptide fused to a T helper epitope. In one aspect, the T epitope is from a peptide selected from the group consisting of a tetanus toxin, an HIV-1 Gag p24 and an HIV-1 Env-gp120. Compositions containing these chimeric proteins and pharmaceutical and immunogenic compositions comprising these chimeric proteins also are part of the present invention. Methods to induce neutralizing antibodies against HIV-1 activity and uses of the chimeric peptides to treat or to prevent HIV-1 infection are also disclosed |
申请公布号 |
EP2326661(A1) |
申请公布日期 |
2011.06.01 |
申请号 |
EP20090809340 |
申请日期 |
2009.08.27 |
申请人 |
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE |
发明人 |
HOVANESSIAN, ARA;KRUST, BERNARD |
分类号 |
C07K14/005;A61K39/00;A61K39/12;A61K39/21 |
主分类号 |
C07K14/005 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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