| 发明名称 |
Mutant interleukin-2 (IL-2) polypeptides |
| 摘要 |
The present invention relates to IL-2 mutants with increased affinity for the IL-2 alpha-receptor subunit (IL-2Rα). The invention thus includes IL-2 mutants with improved biological potency. The invention also includes methods for directed evolution of IL-2α using yeast surface display to generate mutants with increased affinity for IL-2Rα.
|
| 申请公布号 |
US7951360(B2) |
申请公布日期 |
2011.05.31 |
| 申请号 |
US20090535083 |
申请日期 |
2009.08.04 |
| 申请人 |
MASSACHUSETTS INSTITUTE OF TECHNOLOGY |
发明人 |
WITTRUP K. DANE;RAO BALAJI M.;LAUFFENBURGER DOUGLAS A. |
| 分类号 |
C07K14/55;A61K;A61K38/20;C07H21/04;C12P21/04 |
主分类号 |
C07K14/55 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
|
| 地址 |
|
