CHIRAL DERIVATIVES OF 3-PHENYL-PROPIONIC ACID, PARTICULARLY USEFUL FOR THE TREATMENT OF DISEASES ASSOCIATED WITH PPAR-ALPHA OR PPAR-GAMMA

摘要

THE PRESENT INVENTION IS CONCERNED WITH COMPOUNDS OF FORMULA (I) H WHEREIN R1 IS ARYL OR HETEROARYL; R2 IS HYDROGEN, LOWER-ALKYL, OR FLUORO-LOWER-ALKYL; R3 AND R4 INDEPENDENTLY FROM EACH OTHER ARE HYDROGEN, HYDROXYL, HALOGEN, LOWER-ALKYL, FLUOROLOWER-ALKYL, HYDROXYL-LOWER-ALKYL, LOWER-ALKOXY-LOWER-ALKYL, LOWER-ALKOXY, FLUOROLOWER-ALKOXY, HYDROXYL-LOWER-ALKOXY, LOWER-ALKOXY-LOWER-ALKOXY, OR LOWER-ALKENYL, WHEREIN AT LEAST ONE OF R3 AND R4 IS NOT HYDROGEN; R5 IS LOWER-ALKOXY, FLUORO-LOWER-ALKOXY, LOWER-ALKENYLOXY, FLUORO-LOWER-ALKENYLOXY, ARYLOXY, ARL-LOWER-ALKOXY, OR ARYL-FLUORO-LOWER-ALKOXY; R6 IS HYDROGEN OR LOWER-ALKYL; N IS 1; AND PHARMACEUTICALLY ACCEPTABLE SALTS AND/OR PHARMACEUTICALLY ACCEPTABLE ESTERS THEREOF. THE COMPOUNDS OF THE PRESENT INVENTION INHIBIT PPARα AND PPAR SIMULTANEOUSLY. THEY ARE USEFUL FOR THE TREATMENT AND/OR PREVENTION OF DISEASES WHICH ARE ASSOCIATED WITH PPARα AND/OR PPAR, AS, FOR EXAMPLE, DIABETES, AND PARTICULARLY NON-INSULIN DEPEND DIABETES MELLITUS, ELEVATED BLOOD PRESSURE, INCREASED LIPID AND CHOLESTEROL LEVELS, ATHEROSCLEROTIC DISEASES AND METABOLIC SYNDROME.