COMPOSITIONS FOR EXTERNAL APPLICATION, CONTAINING ADENOSYL COBALAMIN FOR IMPROVEMENT OF SKIN DISEASES

摘要

COMPOSITIONS FOR EXTERNAL APPLICATION, CONTAINING ADENOSYL COBALAMIN FOR IMPROVEMENT OF SKIN DISEASES 5 THE PRESENT INVENTION RELATES TO A COMPOSITION FOR EXTERNAL APPLICATION FOR IMPROVING A SKIN DISEASE, AND PARTICULARLY TO A COMPOSITION COMPRISING AS AN ACTIVE INGREDIENT ADENOSYL COBALAMIN (COENZYME B12), WHICH CONSTITUTES COENZYME OF COBALAMIN IN PINOCYTOSIS, THEREBY ENABLING THE IMPROVEMENT TO THE CONVENTIONAL 10 PREPARATION CONTAINING COBALAMINE AND ITS DERIVATIVES, WHICH SHOW DELAYED PHARMACEUTICAL ACTION AND ARE VERY LOW IN BIOAVAILABILITY AS MORE THAN 90OF COBALAMIN OR ITS DERIVATIVES ARE EXCRETED, RELATIVE TO 100OF ADMINISTERED DOSAGE, DUE TO THEIR HIGH MOLECULAR WEIGHT.