摘要 |
SUBSTITUTED AND PYRIDINES AND PYRIDAZINES HAVING ANGIOGENESIS INHIBITING ACTIVITY AND THE GENERALIZED STRUCTURAL FORMULA WHEREIN THE RING CONTAINING A, B, C, D, E, AND L IS PHENYL OR A NITROGEN-CONTAINING HETEROCYCLE; GROUPS X AND Y MAY BE ANY OF A VARIETY OF DEFINED LINKING UNITS; R1 AND R2 MAY BE DEFINED INDEPENDENT SUBSTITUENTS OR TOGETHER MAY BE A RING-DEFINDING BRIDGE; RING J MAY BE AN ARYL, PYRIDYL, OR CYCLOALKYL GROUP; AND G GROUPS MAY BE ANY OF A VARIETY OF DEFINED SUBSTITUENTS. PHARMACEUTICAL COMPOSITIONS CONTAINING THESE MATERIALS, AND METHODS OF TREATING A MAMMAL HAVING A CONDITION CHARACTERIZED BY ABNORMAL ANGIOGENESIS OR HYPERPERMIABILITY PROCESSES USING THESE MATERIALS ARE ALSO DISCLOSED. |