发明名称 |
PYRIMIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE. |
摘要 |
<p>Disclosed are compounds of Formula I, including steroisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, that are useful in modulating PIKK related kinase signaling, e.g., mTOR, and for the treatment of diseases (e.g., cancer) that are mediated at least in part by the dysregulation of the PIKK signaling pathway (e.g., mTOR).</p> |
申请公布号 |
MX2011001196(A) |
申请公布日期 |
2011.05.30 |
申请号 |
MX20110001196 |
申请日期 |
2009.07.31 |
申请人 |
GENENTECH, INC. |
发明人 |
PEI, ZHONGHUA;ORTWINE, DANIEL, FRED;COHEN, FREDERICK;LYSSIKATOS, JOSEPH, P.;BERGERON, PHILIPPE;ESTRADA, ANTHONY;KOEHLER, MICHAEL, F.T.;LAU, KEVIN, HON LUEN;LY, CUONG;ZHAO, XIANRUI |
分类号 |
C07D239/02 |
主分类号 |
C07D239/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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