发明名称 SUBSTITUTED TETRAHYDROPYRAN SPIRO PYRROLIDINONE AND PIPERIDINONE, PREPARATION AND THERAPEUTIC USE THEREOF.
摘要 <p>The present invention discloses and claims a series of substituted N-phenyl-bipyrrolidine carboxamides of formula (I) Wherein R1, R2, m, n and p are as described herein. More specifically, the compounds of this invention are modulators of H3 receptors and are, therefore, useful as pharmaceutical agents, especially in the treatment and/or prevention of a variety of diseases modulated by H3 receptors including diseases associated with the central nervous system. Additionally, this invention also discloses methods of preparation of substituted N-phenyl-bipyrrolidine carboxamides and intermediates therefor.</p>
申请公布号 MX2011004791(A) 申请公布日期 2011.05.30
申请号 MX20110004791 申请日期 2009.12.04
申请人 SANOFI-AVENTIS 发明人 ZHONGLI GAO;DAVID STEFANY;RYAN HARTUNG
分类号 C07D491/107;A61K31/407;A61K31/438;A61P25/00 主分类号 C07D491/107
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