| 摘要 |
Disclosed is a (+)-5-substituited-pyrid-5-yl]-1-azabicyclo[3.2.1]octane corresponding to formula (I) in which R represents a group chosen from pyrazolyl, imidazolyl, triazolyl, oxazolyl, oxadiazolyl, thiazolyl, isothiazolyl, thiadiazolyl and tetrazolyl in the form of base or of acid-addition salt, and also in the form of hydrate or solvate. Also disclosed is a process to prepare said octane, compositions comprising said octane and the use of said octane in the treatment of cognitive impairment; attention impairment; executive function disorders associated with Alzheimer's disease, pathological or normal ageing, Parkinson's disease, trisomy 21, psychiatric pathologies, Korsakoff's alcoholic syndrome, vascular dementia, or cranial trauma; motor disorders observed in Parkinson's disease or other neurological diseases.
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