| 摘要 |
Disclosed is a 7-ALKYNYL-1,8-NAPHTHYRIDONE carboxamide compound of Formula (I) where the substituents are as describe in the specification. Also disclosed is the process for making the compounds of formula (I) and the use of a medicament or composition containing the compound to treat VEGFR-3 tumors, cancers especially glioblastomas, multiple myelomas, myelodysplasic syndromes, Kaposi's sarcomas, cutaneous angiosarcomas, solid tumours, lymphomas, melanomas, breast cancers, colorectal cancers, lung cancers, including non-small-cell cancers, pancreatic cancers, prostate cancers, kidney cancers, head and neck cancers, liver cancer, ovarian cancers, cancers of the respiratory tract and chest, or other tumours expressing VEGFR-3 or involving a process of angiogenesis or of Iymphangiogenesis, arthrosis, restenosis, psoriasis, hemangiomas, lymphangiomas, glaucomas, glomerulonephritis, diabetic nephropathies, nephrosclerosis, thrombotic microangiopathic syndromes, liver cirrhosis, atherosclerosis, organ transplant rejection, or eye diseases involving a process of angiogenesis or of Iymphangiogenesis.
|
