Novel benzoxazine benzimidazole derivatives, pharmaceutical composition comprising same, and a use thereof

摘要

Disclosed is a benzoxazine derivative of formula (1), or a salt, hydrate, solvate, or stereoisomer thereof, where the substituents and variables are as defined in the specification. Also disclosed is the use of the above compound to treat diseases associated with antagonistic activity of vanilloid receptor, such as acute pain, chronic pain, neuropathic pain, postoperative pain, migraines, arthralgia, neuropathy, nerve injury, diabetic neuropathy, neurological illness, neurodermatitis, stroke, bladder hypersensitivity, obesity, irritable bowel syndrome, cough, asthma, Chronic Obstructive Pulmonary Disease, glaucoma, burns, psoriasis, itching, vomiting, irritation of the skin, eyes, or mucous membranes, reflux esophagitis, gastricduodenal ulcers, and inflammatory diseases.