发明名称 |
PROCESS FOR MAKING SALTS OF N-HYDROXY-3-[4-[[[2-(2-METHYL-1H-INDOL-3-YL)ETHYL]AMINO]METHYL]PHENYL]-2E-2-PROPENAMIDE |
摘要 |
Disclosed is a method of preparing the lactate monohydrate salt of N-hydroxy-3-[4- [[[2-(2-methyl-1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2E-2-propenamide comprising the steps of: (a) suspending N-hydroxy-3-[4-[[[2-(2-methyl-1H-indol-3 yl)ethyl]amino]methyl]phenyl]-2E-2-propenamide free base monohydrate in acetone; (b) adding lactic acid dropwise with stirring at ambient temperature, wherein the lactic acid is present in an equimolar amount; (c) stirring the reaction mixture for a time sufficient to cause precipitation of the lactate monohydrate salt; and (d) cooling the reaction mixture.
|
申请公布号 |
NZ572744(A) |
申请公布日期 |
2011.05.27 |
申请号 |
NZ20070572744 |
申请日期 |
2007.06.07 |
申请人 |
NOVARTIS AG |
发明人 |
BAJWA, JOGINDER, S;PARKER, DAVID, JOHN;SLADE, JOEL |
分类号 |
C07D209/14 |
主分类号 |
C07D209/14 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|