| 摘要 |
The present invention relates to influenza vaccine formulations and vaccination regimes for immunizing against influenza disease. In particular the invention relates to vaccine formulations comprising an oil-in-water emulsion adjuvant and optionally 3D-MPL, their use in medicine, in particular their use in augmenting immune responses to influenza antigens, and to methods of preparation, wherein the oil in water emulsion comprises a sterol, a metabolizable oil and an emulsifying agent. The present invention also provides for new prime-boost vaccination regimes for immunizing humans against influenza disease, and in particular for ensuring and ameliorating the immune response to the booster administration, in which a first influenza virus vaccine is administered in the presence of an adjuvant.
|
