| 摘要 |
The present invention relates to a monolithic mono-, bi- or multi-layer structure consisting of composite biomimetic materials for preparing substitutes for the treatment of bone, cartilaginous or osteocartilaginous defects. In particular, the present invention relates to a monolayer cartilaginous substitute consisting of an organic matrix comprising collagen and chitosan and a monolayer osseous substitute consisting of an organic-inorganic composite matrix comprising hydroxyapatite, collagen and chitosan. Moreover, the present invention relates to a monolithic bilayer or multilayer osteocartilaginous substitute comprising a first upper layer consisting of an organic matrix comprising collagen and chitosan and a lower layer consisting of a composite matrix comprising hydroxyapatite, collagen and chitosan. Finally, the present invention relates to the use of said monolayer or bilayer or multilayer structures to prepare said cartilaginous, osseous or osteocartilaginous substitutes for the treatment of articular chondral, bone and osteochondral defects or for the neoformation of a cartilaginous tissue and/or subchondral bone tissue. |
