发明名称 |
VERWENDUNG DES MELANOMDIFFERENZIERUNGS ASSOZIIERTEN GENS (mda-7) ZUR UMWANDLUNG EINES KREBSPHÄNOTYPS |
摘要 |
This invention provides a method for reversing the cancerous phenotype of a cancer cell by introducing a nucleic acid having the melanoma differentiation associated gene ( mda-7 ) into the cell under conditions that permit the expression of the gene so as to thereby reverse the cancerous phenotype of the cell. This invention also provides a method for reversing the cancerous phenotype of a cancer cell by introducing the gene product of the above-described gene into the cancerous cell so as to thereby reverse the cancerous phenotype of the cell. This invention also provides a pharmaceutical composition having an amount of a nucleic acid having the melanoma differentiation associated gene ( mda-7 ) or the gene product of a melanoma differentiation associated gene ( mda-7 ) effective to reverse the cancerous phenotype of a cancer cell and a pharmaceutically acceptable carrier. |
申请公布号 |
DE69740175(D1) |
申请公布日期 |
2011.05.26 |
申请号 |
DE1997640175 |
申请日期 |
1997.08.15 |
申请人 |
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK |
发明人 |
FISHER, PAUL B. |
分类号 |
A61K9/127;A61K48/00;A61K31/16;A61K35/76;A61K38/17;A61K39/395;A61P35/00 |
主分类号 |
A61K9/127 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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