发明名称 |
HIGH DENSITY COMPOSITIONS CONTAINING POSACONAZOLE AND FORMULATIONS COMPRISING THE SAME |
摘要 |
The present application provides novel compositions comprising posaconazole and a polymer wherein the composition has a glass transition temperature (Tg) of less than about 1100 C. The application also describes compositions comprising posaconazole and a polymer having a bulk density of greater than about 0.4 mg/mL. The application also describes compositions comprising posaconazole and a polymer which provide an exposure (AUCtf) of at least about 10,000 ng·hr/mL when administered to a patient in a fasted state. The application also describes a novel process for preparing these compositions. The preff erred polymer is HPMCAS. Preferably the composition is an extruded material.
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申请公布号 |
US2011123627(A1) |
申请公布日期 |
2011.05.26 |
申请号 |
US20090999547 |
申请日期 |
2009.04.15 |
申请人 |
FANG LARRY YUN;HARRIS DAVID;KRISHNA GOPAL;MOTON JR ALLEN E;PRESTIPINO RUSSELL C;STEINMAN MARC;WAN JIANSHENG;WASKIN HETTY ANNE |
发明人 |
FANG LARRY YUN;HARRIS DAVID;KRISHNA GOPAL;MOTON, JR. ALLEN E.;PRESTIPINO RUSSELL C.;STEINMAN MARC;WAN JIANSHENG;WASKIN HETTY ANNE |
分类号 |
A61K31/496;A61K9/14;A61P31/10 |
主分类号 |
A61K31/496 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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