| 摘要 |
PROBLEM TO BE SOLVED: To provide a method for efficiently synthesizing (R)-2-(3-diisopropylamino-1-phenylpropyl)-4-(hydroxymethyl)-phenol isobutyrate (Fesoterodine) and its (S)-enantiomer fesoterodine, by which the synthesis of the Fesoterodine and its (S)-enantiomer fesoterodine can be attained in high purity and in an industrial scale from low cost starting materials. SOLUTION: The method for producing the Fesoterodine and its (S)-enantiomer includes resolving a racemic compound represented by formula (II) (wherein Ra is 1C to 6C alkyl) by the formation of a diastereomer salt of the racemic compound with an optically active organic acid, reducing the ester portion, and then isobutylating the phenolic hydroxyl group. COPYRIGHT: (C)2011,JPO&INPIT
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