发明名称 |
ASSAY FOR EVALUATING AFFINITY AND SPECIFICITY OF LIGAND-ALBUMIN BINDING |
摘要 |
A method for identifying a ligand or compound which binds to albumin comprises the steps of contacting a reaction mixture comprising a site-specific probe and albumin in the presence and the absence of the ligand or compound and measuring either dissociation constant KD, inhibitor concentration IC50 or fluorescence displacement; whereby a change in KD, IC50 and/or fluorescence in the presence of the ligand or compound is indicative of the ligand or compound binds to albumin.
|
申请公布号 |
US2011124120(A1) |
申请公布日期 |
2011.05.26 |
申请号 |
US20100885865 |
申请日期 |
2010.09.20 |
申请人 |
KRANZ JAMES K;TODD GABRIELLE C;TODD MATTHEW J |
发明人 |
KRANZ JAMES K.;TODD GABRIELLE C.;TODD MATTHEW J. |
分类号 |
G01N33/53 |
主分类号 |
G01N33/53 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|