| 发明名称 |
MODULATION OF IMMUNOSTIMULATORY PROPERTY OF OLIGONUCLEOTIDE-BASED COMPOUND BY UTILIZING MODIFIED IMMUNOSTIMULATORY DINUCLEOTIDE |
| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide an immunomer and an immunostimulatory oligonucleotides for use in methods for generating an immune response or for treating a patient in need of immunostimulation. <P>SOLUTION: The immunomers preferably comprise novel purines, at least two oligonucleotides linked at their 3' ends, and internucleoside linkages or functionalized nucleobase or sugar to a non-nucleotidic linker, wherein at least one of the oligonucleotides is the immunomodulatory oligonucleotide and has an accessible 5' end. <P>COPYRIGHT: (C)2011,JPO&INPIT |
| 申请公布号 |
JP2011101647(A) |
申请公布日期 |
2011.05.26 |
| 申请号 |
JP20100272747 |
申请日期 |
2010.12.07 |
| 申请人 |
IDERA PHARMACEUTICALS INC |
发明人 |
AGRAWAL SUDHIR;BHAGAT LAKSHMI;YU DONG;KANDIMALLA EKAMBAR |
| 分类号 |
C12N15/117;A61K;A61K31/7088;A61K39/00;A61K39/35;A61K39/39;A61K39/395;A61K45/00;A61K48/00;A61P11/00;A61P11/06;A61P17/00;A61P29/00;A61P31/04;A61P35/00;A61P37/02;A61P37/06;A61P37/08;C07H21/00;C07H21/02;C07H21/04;C12N15/11;C12Q1/68 |
主分类号 |
C12N15/117 |
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