发明名称 SINGLE DOMAIN ANTIBODIES DIRECTED AGAINST EPIDERMAL GROWTH FACTOR RECEPTOR AND USES THEREFOR
摘要 The present invention relates to polypeptides derived from single domain heavy chain antibodies directed to Epidermal Growth Factor Receptor. It further relates to single domain antibodies that are Camelidae VHHs. It further relates to methods of administering said polypeptides orally, sublingually, topically, intravenously, subcutaneously, nasally, vaginally, rectally or by inhalation. It further relates to protocols for screening for agents that modulate the Epidermal Growth Factor Receptor, and the agents resulting from said screening. The invention further a method for delivering therapeutic molecules to the interior of cells.
申请公布号 US2011123529(A1) 申请公布日期 2011.05.26
申请号 US201113016709 申请日期 2011.01.28
申请人 ABLYNX N.V. 发明人 LAEREMANS TOON;VAN BERGEN EN HENEGOUWEN PAUL M. P.;SILENCE KAREN;VAECK MARK
分类号 A61K39/395;C07H21/00;C07K2/00;C07K16/00;C12N5/071;C12N5/10;C12N15/63;C12P21/00 主分类号 A61K39/395
代理机构 代理人
主权项
地址